![]() ![]() Risk of biasor fair if it has three scores out of six domains. Good quality when it has four or more positive, which showed a low Risk of Bias and Quality Assessment: Studies were scored as Study wasremoved we noted a slight change in confidence interval However, the direction of confidence intervalslightly changed from ![]() Measures,by removing low weight study, the OR did not change Level Of Heterogeneity: A sensitivity test was performedīy removing one study at a time, and recalculating the effect Sensitivity Analysis for Studies That Showed A Substantial Our eligibility criteria 12 studies were criticallyĪnalysed and further included in the final synthesis (Figure 1). Ī probability values of less than 0.05 were considered significantĪ search on PubMed database yielded 64 studies, based on Publication bias was visually assessed using the funnel plots Nephropathy, stroke, hypertension and vitamin B12 deficiency. Subgroup analyses were performed according toĭifferent events, including CVD, anaemia, neuropathy, retinopathy, Model was used for studies which showed no presence of Meta-analyses in case of substantial heterogeneity while the fixedeffect High clinical heterogeneity, a random effects model was used for No and substantial level of heterogeneity respectively. In the case where heterogeneity was observed,Īn attempt to find sources of heterogeneity was made through subgroup analysis and sensitivity tests. Heterogeneity was tested withĬochrane chi-square statistics and measured with the Higgins Odds of adverse events and metformin-associated with higher odds Result: Metformin increases risk of vitamin B12 deficiency OR, 95%CI[2.41Īssociated with exposure of metformin, metformin not affecting Elevenstudies investigating the impact of metformin in type 2ĭiabetes mellitus were included in final synthesis after critical evaluation. Methods: A literature search was conducted on PubMed-Medline database up The efficacy of this drug in the prevention ofcardiovascular disease associated with type Background: Metformin is used as a first-line treatment in patients with type 2ĭiabetes mellitus and have a significant impact on the prevention of complicationsĪssociated with type 2 diabetes mellitus.Īim: To evaluate the effect of metformin treatment on vitamin B12 level andĪssociated events in patientsliving with type 2 diabetes mellitus and further evaluate ![]()
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